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Glomerulosclerosis: Renal biopsy in FLD

Case kindly shared by Drs. Giuliano Boscutti and Stefano Pizzolitto, Udine.

Fig. 1: Expansion of the mesangial matrix; irregular bubble appearance of the basement membrance, foam cells in capillaries and mesangial areas.

Fig. 2: Small lipid droplets in the mesangium (Oil Red staining; magnification x400)
Fig. 3: Expansion of the mesangial matrix; nuclei of mesangial cells are hypertrophic and with irregular contour; numerous lipid droplets (*) are seen in the cytoplasm (electron microscopy, magnification x3000).

Fig. 4: Expansion of the basement membranes with irregular bubbles appearence of the basement membranes (electron microscopy, magnification x7000).